About TME Facility

Tumor micro-environment (TME), particularly cells and molecules that avoid presence and/or activation of reactive lymphocytes, is captured by multiplex in situ stainings and advanced analysis tools; charting TME’s heterogeneity is critical to understanding tumor evolution and clinical response to therapies.

Tumor micro-environment

The tumor microenvironment (TME) represents the surrounding of tumor cells, including endothelial cells, fibroblasts, immune cells, and their products, such as signaling molecules (eicosanoids, cytokines) and structural components (extracellular matrix). In cancer research, the modulation of the TME has gained a forefront position. Recent studies have demonstrated that diagnosis and therapy selection for cancer patients may benefit significantly from the discovery and validation of changes in TME, particularly those that are related to immune evasion. In fact, type, density and location of immune effector cells in various tumor types provide better prognostic values in comparison to conventional clinico-pathological criteria. To accurately chart TME, it is critical to simultaneously measure the presence and quantity of multiple proteins in the context of intact tissue architecture thereby ensuring correct identification and localization of immune effector and suppressor cells (or their subsets), fibroblasts, endothelial cells, and molecules representing their activation state.

Get in Touch

Contact TME Facility to get more information or to get your project under way!

Pay us a visit

Laboratory of Tumor immunology 
Department of Medical Oncology
Erasmus MC-Cancer Center
Josephine Nefkens Institute
Wytemaweg 80, 3015 CN Rotterdam

Contact us

Dr. H. Emrah Balcıoğlu 
+31 (0) 10 7041753