Thanks to the Leica BOND-RX fully automated stainer, stainings within the TME-Facility can be performed in an automated fashion. It is also open for usage to collaborators, also for other modes of usage (e.g. IF, IHC, FISH, etc.; see BOND-RX website for full description). It enables customization of all steps such as preparation (baking and dewax options), antigen retrieval (incubation time and temperature), ISH probes (probe application and removal options) and staining (incubation times, temperatures, dispense types and more). With high throughput, it also enables testing of different conditions in an automated fashion to maximize the assay viability in minimal time, and thanks to small volumes used, with minimal reagents.